![]() Typically, a healthy patient with Hughes syndrome suddenly develops multiple clots in various vital organs, including the brain, heart, lungs or liver. This is a rare but extremely life-threatening complication of Hughes syndrome. The blood of a woman with Hughes syndrome may be too sticky to pass through the tiny blood vessels of the placenta. During pregnancy, the placenta provides the growing baby with oxygen and nutrients from the mother’s bloodstream. Hughes syndrome has been identified as a major cause of recurrent miscarriage. Catastrophic antiphospholipid syndrome.Low blood platelet count (thrombocytopenia).Without treatment, Hughes syndrome can cause many symptoms and complications, including: In most of these cases, the temporary production of this abnormal blood protein doesn’t cause any harm. Some drugs such as cocaine, quinine and antibiotics can also cause the blood to make antiphospholipid antibodies. It is thought that about two in every 100 healthy people have mild but detectable levels of antiphospholipid antibodies following illnesses such as hepatitis or malaria. It is not clear what triggers the production of antiphospholipid antibodies. Clumping of platelets causes the build-up of clots. This autoimmune reaction results in platelets sticking together. The reason for this overlap is unclear.Īntiphospholipid antibodies bind to molecules in the blood called phospholipids (a phospholipid is a fat or ‘lipid’ bound with phosphorus). While most people with Hughes syndrome don’t have lupus, about one in every two people with lupus has Hughes syndrome. The antiphospholipid antibody is an abnormal type of blood protein that is usually found only in people who have certain diseases such as Hughes syndrome or systemic lupus erythematosus. There is no cure, but medical treatment can ease symptoms and reduce the risk of complications. It is a lifelong condition and the causes are unclear. Hughes syndrome is one of the more common autoimmune conditions, yet it is not as well known as some other diseases of the immune system. Any organ or limb can be affected, depending on the site of the blood clot. Without medical treatment, blood clots may lodge in veins or arteries and cause dangerous complications. People with certain autoimmune diseases such as systemic lupus erythematosus (SLE) are at increased risk of having Hughes syndrome. Hughes syndrome is sometimes called ‘sticky blood syndrome’ because people with this condition are more likely to form clots in blood vessels (thromboses). The immune system produces abnormal blood proteins called antiphospholipid antibodies, which cause blood platelets to clump together. Hughes syndrome, or antiphospholipid antibody syndrome (APS), is an autoimmune condition that causes thickening of the circulating blood. ![]()
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